Darzalex 400mg (Daratumumab)

Description

Darzalex 400mg (Daratumumab)

Darzalex 400mg (Daratumumab) is an anti-cancer drug. It binds to CD38, which multiple myeloma cells overexpress. Buy Darzalex 400mg  from reliable at low prices.

Daratumumab (trade name Darzalex) is an anti-cancer drug. It binds to CD38, which multiple myeloma cells overexpress. Daratumumab was originally developed by Genmab, but it is now being jointly developed by Genmab along with the Johnson & Johnson subsidiary Janssen Biotech, which acquired worldwide commercialization rights to the drug from Genmab.

Daratumumab was given breakthrough therapy drug status in 2013 for multiple myeloma. It was awarded orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma.

Darzalex 400mg (Daratumumab)

In November 2015, the U.S. Food and Drug Administration (FDA) approved daratumumab for treatment of multiple myeloma in patients who had received at least three prior therapies. In May 2016 daratumumab was also conditionally approved by the European Medicines Agency for treatment of multiple myeloma.

In November 2016, the FDA approved daratumumab in combination with lenalidomide or bortezomib and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.

In May 2018, the FDA expanded the approval of daratumumab for use in combination with bortezomib, melphalan and prednisone to include the treatment of patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant.

The European Commission granted a marketing authorisation on 20 May 2016. In the European Union it is indicated as monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, whose prior therapy included a proteasome inhibitor and an immunomodulatory agent and who have demonstrated disease progression on the last therapy.

Daratumumab can also bind to CD38 present on red blood cells and interfere with routine testing for clinically significant antibodies. Patients will show a panreactive antibody panel, including a positive auto-control, which tends to mask the presence of any clinically significant antibodies.