OPDIVO 40 mg and what it is used?
OPDIVO is a medicine for the treatment of
- advanced melanoma (a type of skin cancer) in adults
- advanced non-small cell lung carcinoma (a form of lung cancer) in adults
- advanced renal cell carcinoma (advanced kidney cancer) in adults.
It contains the active ingredient Nivolumab, a monoclonal antibody. This is a type of protein, which is designed to recognize a specific target substance in the body and bind to.
Nivolumab binds to a target protein called “Programmed Death-1 receptor” (PD-1), which can shut down the activity of T-cells (T-cells are a type of white blood cells that are part of the immune system, the body’s natural defenses, ). Through its binding to PD-1 Nivolumab blocks the action of this protein, thereby preventing the switching off your T-cells. Thus, the activity of T cells is promoted against melanoma, lung or kidney cancer cells.
OPDIVO can be applied in combination with ipilimumab. It is important that you also read the leaflet for this drug. If you have any questions about ipilimumab, contact your doctor.
What you need to know before applying OPDIVO 40 mg?
OPDIVO 40 mg Do not use taken,
- if you are allergic are called against Nivolumab or in Section 6 (Content of the pack and other information) other ingredients of this medicine. Ask your doctor if you are unsure.
Warnings and Precautions
Please talk to your doctor before you apply OPDIVO 40 mg . OPDIVO can cause the following:
- Problems with the lungs such as wheezing or coughing. These may be signs of pneumonia (pneumonitis or interstitial lung disease).
- Diarrhea (watery, loose or soft stools) or symptoms of inflammatory bowel disease (colitis) such as abdominal pain and mucus or blood in the stool.
- Inflammation of the liver (hepatitis) signs and symptoms of hepatitis may include abnormal liver function tests, yellowing of the eyes or skin (jaundice), be pain in the right abdomen area or fatigue.
- Abnormal renal function tests or kidney problems. Signs and symptoms may include among other abnormal renal function tests or a debased urine volume.
- Problems of the endocrine glands (including the pituitary, thyroid and adrenal glands), whereby the gland function may be impaired. Signs and symptoms that the glands do not work properly, including fatigue (extreme tiredness), weight changes or headaches and vision problems may be.
- Diabetes (symptoms include among others excessive thirst, greatly increased urine output, increased appetite with weight loss, feeling of tiredness, sleepiness, weakness, depression awareness, irritability and general malaise) or diabetic ketoacidosis (caused by diabetes acid in the blood).
- Skin inflammation, which rash and itching of the skin may result.
Inform your doctor immediately if you have any of these signs or symptoms or they get worse. Do not try to treat your symptoms with other medicines. Your doctor
- Give you other medicines to prevent complications and to reduce the symptoms,
- omit the next dose OPDIVO
- cancel or treatment with OPDIVO entirely.
Please note that these signs and symptoms sometimes delays occur and may develop weeks or months after the last infusion. Before treatment, your doctor will examine your overall health. It also occurs during your treatment blood tests performed.
Discuss with your doctor or nurse before you receive OPDIVO when
- An autoimmune disease have (a state in which the body attacks its own cells);
- A melanoma of the eye have;
- You have previously received ipilimumab, another drug for the treatment of melanoma, and this medicine you have serious side effects have occurred;
- You have been told that when you have made cancer metastases in the brain;
- have a history of pneumonia occurred;
- You drugs have taken, which suppress your immune system.
Children and adolescents
OPDIVO should not be used in children and adolescents under 18 years.
Application of OPDIVO with other medicines
Before you apply OPDIVO, tell your doctor if you are taking medicines / apply that suppress the immune system, such as corticosteroids, as these medicines may influence the effect of OPDIVO. If you are treated once with OPDIVO, but your doctor may prescribe corticosteroids to alleviate possible side effects during treatment. This will not affect the effect of the drug.
Tell your doctor if you take other medicines / taking or have recently taken any other medicines / applied. Take during your treatment any other medicineswithout having the previously discussed with your doctor.
pregnancy and breast feeding period
Inform your doctor if you are pregnant, think you may be pregnant, if you are planning to become pregnant or if you are breastfeeding.
Use OPDIVO not, if you are pregnant, unless your doctor has specifically arranged this. The effects of OPDIVO during pregnancy are not known, but it is possible that the active ingredient Nivolumab can harm the unborn baby.
- If you can get children as a woman, you need an effective method of contraception to use, while being treated with OPDIVO and up to and including at least 5 months after the last dose OPDIVO.
- If you become pregnant during treatment with OPDIVO, tell your doctor .
It is not known whether Nivolumab passes into breast milk. A risk to breastfed infants can not be excluded. Ask your doctor whether you can breast-feed during or after treatment with OPDIVO.
Driving and using machines
It is unlikely that Nivolumab impair the ability to drive and the ability to operate machinery; but you should be careful until you are sure that you Nivolumab not impaired in these activities.