treatment of adult patients with relapsing-remitting multiple sclerosis.
hypersensitivity to the active substance or any of the excipients;
severe form of hepatic insufficiency (class C on the Child-Pugh scale);
Pregnancy (before beginning therapy with teriflunomide, pregnancy should be excluded), breast-feeding;
women with preserved childbearing potential who do not use reliable methods of contraception and at a plasma concentration of teriflunomide above 0.02 mg / l;
severe immunodeficiency, such as AIDS;
severe disturbance of bone marrow hematopoiesis, including clinically significant anemia, leukopenia, neutropenia, or thrombocytopenia;
severe renal failure requiring hemodialysis;
severe active infections;
deficiency of lactase, galactose intolerance, glucose-galactose malabsorption;
age to 18 years.
Abadgio should be administered with caution to patients aged 65 years and older due to insufficient data on efficacy and safety in this age group.
Infectious complications: very often – influenza, upper respiratory tract infections, urinary tract infections, laryngitis, foot mycosis; often – bronchitis, sinusitis, pharyngitis, cystitis, viral gastroenteritis, oral cavity herpes, periodontal infections.
From the immune system: often – mild allergic reaction.
Mental disorders: often – anxiety.
From the nervous system: very often – paresthesia; often – lumbosacral radiculitis, carpal tunnel disease, hyperesthesia, neuralgia, peripheral neuropathy.
From the cardiovascular system: often – hypertension.
From the respiratory system: interstitial lung diseases *.
From the digestive system: very often – diarrhea, nausea; often – vomiting, toothache; very rarely – pancreatitis *.
From the skin and subcutaneous tissues: very often – alopecia, often – a rash, acne.
From the musculoskeletal system and connective tissue: often – musculo-skeletal pain, myalgia.
From the kidneys and urinary tract: often – pollakiuria.
From the side of the reproductive system: often – menorrhagia.
Reaction at the injection site, complications of the procedure: often – pain, post-traumatic pain.
Laboratory indicators: very often – an increase in the level of alanine aminotransferase; often – an increase in the level of gamma-glutamyltransferase, an increase in the level of aspartate aminotransferase, weight reduction, a decrease in the number of neutrophils, a decrease in the number of leukocytes.
Injury, poisoning and complications of the procedure: often – post-traumatic pain.